What is Next-Generation Sequencing?
NGS (Next-Generation Sequencing), also known as high-throughput DNA sequencing, is a method used for comprehensive genetic screening of embryos.
NGS is performed during the process of in vitro fertilization (IVF) and its purpose is to identify embryos that may carry potential genetic diseases and prevent their use. This technology enables faster and more accurate analysis of genetic material, allowing it to be utilized for this purpose.
Compared to the FISH technique, which screens embryos for a limited number of chromosomal abnormalities, NGS allows for the examination of all chromosomes for numerical or structural abnormalities (PGT-A). Embryos found to have any chromosomal abnormalities are excluded from the treatment, and only healthy embryos are selected for embryo transfer. This is how we can briefly describe comprehensive genetic screening of embryos.
How is Next-Generation Sequencing (NGS) Performed?
In the process of in vitro fertilization, a suitable biopsy sample is taken from the obtained embryos. The genetic codes within the sample are extensively analyzed using state-of-the-art technological devices. This analysis allows for the comprehensive visualization of the entire chromosome map of the embryos, enabling the detection of chromosomal abnormalities. Following the screening, embryos with normal chromosomal structure are transferred to the mother’s uterus, thereby increasing the chances of a successful pregnancy.
What Is Looked For In The Chromosome Test?
Next-Generation Sequencing (NGS) allows for the examination of all chromosomes for numerical or structural abnormalities. Embryos that are identified with any chromosomal abnormalities are excluded from the treatment, and only healthy embryos are selected for embryo transfer.
Why is Chromosome Analysis Requested?
Next-Generation Sequencing (NGS) is a method used in in vitro fertilization (IVF) procedures, where all chromosomes (23 pairs) of the embryos can be individually examined before transferring them to the uterus.
This method allows for the visualization of the complete chromosomal profile of the examined embryos, enabling the detection of chromosomal abnormalities. Embryos that are identified as genetically abnormal are not selected for transfer. It is particularly sought after in cases of recurrent IVF failures or miscarriages. At our hospital, we achieve high success rates in IVF treatments with comprehensive chromosome screening.
How Much Does Next-Generation Sequencing Cost?
The Next-Generation Sequencing (NGS) procedure performed at our clinic includes the biopsy stage conducted in our laboratory, while the genetic analysis and reporting are carried out by IGENOMIX, a globally recognized company with central facilities in many countries. To obtain detailed information regarding pricing and the process, you can fill out our contact form or reach us via WhatsApp.